作者
Razvan I Panea, Cassandra L Love, Jennifer R Shingleton, Anupama Reddy, Jeffrey A Bailey, Ann M Moormann, Juliana A Otieno, John Michael Ong’echa, Cliff I Oduor, Kristin MS Schroeder, Nestory Masalu, Nelson J Chao, Megan Agajanian, Michael B Major, Yuri Fedoriw, Kristy L Richards, Grzegorz Rymkiewicz, Rodney R Miles, Bachir Alobeid, Govind Bhagat, Christopher R Flowers, Sarah L Ondrejka, Eric D Hsi, William WL Choi, Rex KH Au-Yeung, Wolfgang Hartmann, Georg Lenz, Howard Meyerson, Yen-Yu Lin, Yuan Zhuang, Micah A Luftig, Alexander Waldrop, Tushar Dave, Devang Thakkar, Harshit Sahay, Guojie Li, Brooke C Palus, Vidya Seshadri, So Young Kim, Randy D Gascoyne, Shawn Levy, Minerva Mukhopadyay, David B Dunson, Sandeep S Dave
发表日期
2019/11/7
期刊
Blood, The Journal of the American Society of Hematology
卷号
134
期号
19
页码范围
1598-1607
出版商
American Society of Hematology
简介
Burkitt lymphoma (BL) is an aggressive, MYC-driven lymphoma comprising 3 distinct clinical subtypes: sporadic BLs that occur worldwide, endemic BLs that occur predominantly in sub-Saharan Africa, and immunodeficiency-associated BLs that occur primarily in the setting of HIV. In this study, we comprehensively delineated the genomic basis of BL through whole-genome sequencing (WGS) of 101 tumors representing all 3 subtypes of BL to identify 72 driver genes. These data were additionally informed by CRISPR screens in BL cell lines to functionally annotate the role of oncogenic drivers. Nearly every driver gene was found to have both coding and non-coding mutations, highlighting the importance of WGS for identifying driver events. Our data implicate coding and non-coding mutations in IGLL5, BACH2, SIN3A, and DNMT1. Epstein-Barr virus (EBV) infection was associated with higher mutation load …
学术搜索中的文章
RI Panea, CL Love, JR Shingleton, A Reddy, JA Bailey… - Blood, The Journal of the American Society of …, 2019