作者
Marc R Dweck, Marcus WL Chow, Nikhil V Joshi, Michelle C Williams, Charlotte Jones, Alison M Fletcher, Hamish Richardson, Audrey White, Graham McKillop, Edwin JR van Beek, Nicholas A Boon, James HF Rudd, David E Newby
发表日期
2012/4/24
期刊
Journal of the American College of Cardiology
卷号
59
期号
17
页码范围
1539-1548
出版商
American College of Cardiology Foundation
简介
Objectives
With combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of active plaque calcification and inflammation, respectively.
Background
The noninvasive assessment of coronary artery plaque biology would be a major advance particularly in the identification of vulnerable plaques, which are associated with specific pathological characteristics, including micro-calcification and inflammation.
Methods
We prospectively recruited 119 volunteers (72 ± 8 years of age, 68% men) with and without aortic valve disease and measured their coronary calcium score and 18F-NaF and 18F-FDG uptake. Patients with a calcium score of 0 were used as control subjects and compared with those with calcific atherosclerosis (calcium score >0).
Results
Inter-observer repeatability of …
学术搜索中的文章
MR Dweck, MWL Chow, NV Joshi, MC Williams… - Journal of the American College of Cardiology, 2012