作者
LP Carvalho, S Passos, O Bacellar, M Lessa, Roque Pacheco de Almeida, A Magalhaes, Walderez Ornelas Dutra, KJ Gollob, P Machado, A Ribeiro De Jesus
发表日期
2007/5
期刊
Parasite immunology
卷号
29
期号
5
页码范围
251-258
出版商
Blackwell Publishing Ltd
简介
Cutaneous (CL) and mucosal leishmaniasis (ML) are characterized by a predominant type 1 immune response (IFN‐γ and TNF‐α production) and strong inflammatory response in the lesions with few parasites. This exacerbated type 1 response is more evident in ML as compared to CL. Our main hypothesis is that a differential immune regulation of T cell activation leads to over reactive T cells in ML. In the present study, we investigated immunological factors that could explain the mechanisms behind it by comparing some immune regulatory mechanisms between ML and CL patients: frequency of cells expressing co‐stimulatory molecules, apoptotic markers, T cell activation markers; and ability of neutralizing antibodies to IL‐2, IL‐12 and IL‐15 do down‐regulate IFN‐γ production in leishmania antigen‐stimulated peripheral blood mononuclear cells (PBMC). Interestingly, in CL anti‐IL‐2 and anti‐IL‐15 …
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LP Carvalho, S Passos, O Bacellar, M Lessa… - Parasite immunology, 2007