作者
Herman T Den Dekker, Agnes MM Sonnenschein-Van Der Voort, Johan C De Jongste, Isabella Anessi-Maesano, S Hasan Arshad, Henrique Barros, Caroline S Beardsmore, Hans Bisgaard, Sofia Correia Phar, Leone Craig, Graham Devereux, C Kors Van Der Ent, Ana Esplugues, Maria P Fantini, Claudia Flexeder, Urs Frey, Francesco Forastiere, Ulrike Gehring, Davide Gori, Anne C Van Der Gugten, A John Henderson, Barbara Heude, Jesús Ibarluzea, Hazel M Inskip, Thomas Keil, Manolis Kogevinas, Eskil Kreiner-Møller, Claudia E Kuehni, Susanne Lau, Erik Mélen, Monique Mommers, Eva Morales, John Penders, Katy C Pike, Daniela Porta, Irwin K Reiss, Graham Roberts, Anne Schmidt, Erica S Schultz, Holger Schulz, Jordi Sunyer, Matias Torrent, Maria Vassilaki, Alet H Wijga, Carlos Zabaleta, Vincent WV Jaddoe, Liesbeth Duijts
发表日期
2016/4/1
期刊
Journal of allergy and clinical immunology
卷号
137
期号
4
页码范围
1026-1035
出版商
Mosby
简介
Background
Children born preterm or with a small size for gestational age are at increased risk for childhood asthma.
Objective
We sought to assess the hypothesis that these associations are explained by reduced airway patency.
Methods
We used individual participant data of 24,938 children from 24 birth cohorts to examine and meta-analyze the associations of gestational age, size for gestational age, and infant weight gain with childhood lung function and asthma (age range, 3.9-19.1 years). Second, we explored whether these lung function outcomes mediated the associations of early growth characteristics with childhood asthma.
Results
Children born with a younger gestational age had a lower FEV1, FEV1/forced vital capacity (FVC) ratio, and forced expiratory volume after exhaling 75% of vital capacity (FEF75), whereas those born with a smaller size for gestational age at birth had a lower FEV1 but higher FEV1 …
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HT Den Dekker, AMM Sonnenschein-Van Der Voort… - Journal of allergy and clinical immunology, 2016