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O‐GlcNAc transferase (OGT) is the enzyme catalyzing protein O‐GlcNAcylation by addition of a single O‐linked‐β‐N‐acetylglucosamine molecule (O‐GlcNAc) to nuclear and cytoplasmic targets, and it uses uridine diphosphate‐N‐acetylglucosamine (UDP‐GlcNAc) as a donor. As UDP‐GlcNAc is the final product of the nutrient‐sensing hexosamine signaling pathway, overexpression or knockout of ogt in mammals or invertebrate models influences cellular nutrient‐response signals and increases susceptibility to chronic diseases of aging. Evidence shows that OGT expression levels decrease in tissues of older mice and rats. However, how OGT expression is modulated in the aging process remains poorly understood. In Caenorhabditis elegans, the exclusive mammalian OGT ortholog OGT‐1 is crucial for lifespan control. Here, we observe that worm OGT‐1 expression gradually reduces during aging. By …