作者
Marla C Dubinsky, Eric A Vasiliauskas, Hardeep Singh, Maria T Abreu, Kostas A Papadakis, Tram Tran, Paul Martin, John M Vierling, Stephen A Geller, Stephan R Targan, Fred F Poordad
发表日期
2003/8/1
期刊
Gastroenterology
卷号
125
期号
2
页码范围
298-303
出版商
WB Saunders
简介
BACKGROUND & AIMS
Thioguanine (6-TG) has been studied as an alternative thiopurine in inflammatory bowel disease (IBD). Short-term safety and efficacy data were favorable. Experience with 6-TG in patients with acute lymphoblastic leukemia raised long-term safety concerns when implicated in nodular regenerative hyperplasia (NRH) of the liver and portal hypertension. The aim of this study was to describe the association between 6-TG and NRH in IBD.
METHODS
Liver chemistries and complete blood counts were monitored, and patients were encouraged to undergo liver biopsy. Clinical data were collected by chart review, and associations were tested by univariate and multivariable analyses. Patients were classified based on the presence (group 1) or absence (group 2) of laboratory abnormalities.
RESULTS
Laboratory abnormalities occurred in 29 of 111 patients (26%). Elevations of liver enzymes and …
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MC Dubinsky, EA Vasiliauskas, H Singh, MT Abreu… - Gastroenterology, 2003