作者
Gil Y Melmed, Nik Agarwal, Robert W Frenck, Andrew F Ippoliti, Patricio Ibanez, Konstantinos A Papadakis, Peter Simpson, Cristina Barolet-Garcia, Joel Ward, Stephan R Targan, Eric A Vasiliauskas
发表日期
2010/1/1
期刊
Official journal of the American College of Gastroenterology| ACG
卷号
105
期号
1
页码范围
148-154
出版商
LWW
简介
OBJECTIVES:
The treatment of inflammatory bowel disease (IBD) often includes immunosuppressive medications, which may increase the risk of vaccine-preventable illnesses. We aimed to assess the impact of immunosuppression on immune responses to pneumococcal vaccination in patients with IBD.
METHODS:
The study design consists of a prospective controlled clinical trial. This study was carried out at a tertiary-care IBD clinic. The subjects for the study belonged to one of the following three groups: adult patients with IBD on combination TNF-blockers and immunomodulators (Group A), those without immunosuppressive therapy (Group B), and age-matched healthy controls (Group C). The treatment consisted of immunization with 23-valent pneumococcal polysaccharide vaccines (PSVs). The main outcome was immune response for five serotypes defined as a twofold or greater increase from pre-vaccination …
引用总数
学术搜索中的文章
GY Melmed, N Agarwal, RW Frenck, AF Ippoliti… - Official journal of the American College of …, 2010