作者
William S Mow, Eric A Vasiliauskas, Ying-Chao Lin, Phillip R Fleshner, Konstantinos A Papadakis, Kent D Taylor, Carol J Landers, Maria T Abreu-Martin, Jerome I Rotter, Huiying Yang, Stephan R Targan
发表日期
2004/2/1
期刊
Gastroenterology
卷号
126
期号
2
页码范围
414-424
出版商
WB Saunders
简介
Background & Aims
Crohn’s disease patients can be characterized by antibody responses against Crohn’s disease-related bacterial sequence, Escherichia coli outer membrane porin C, Saccharomyces cerevisiae (oligomannan), and neutrophil nuclear antigens. Our aim was to determine whether expression of antibodies against Crohn’s disease-related bacterial sequence and Escherichia coli outer membrane porin C is associated with distinct phenotypic manifestations.
Methods
Sera from 303 patients were tested for antibodies to the Crohn’s disease-related bacterial sequence (I2), anti-Escherichia coli outer membrane porin C, anti-Saccharomyces cerevisiae, and perinuclear antineutrophil cytoplasmic antibodies and for 3 Crohn’s disease-associated variants of the NOD2 gene (R702W, G908R, and 1007fs) and compared with clinical data.
Results
Patients expressing I2 were more likely to have fibrostenosing …
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WS Mow, EA Vasiliauskas, YC Lin, PR Fleshner… - Gastroenterology, 2004