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There is a psychosocial component to many physical health conditions, such that chronic and acute psychological distress can trigger the physiological stress response and lead to unhealthy lifestyle behaviors which may alone and in combination contribute to risk for, or exacerbate symptoms of, many medical conditions including cancer, pain, cardiovascular conditions, HIV/AIDS, and irritable bowel syndrome. Mindfulness-based interventions help to target many elements of the disease process which contribute to the experience of subjective stress including lack of control, unpredictability, symptom burden, fear of death, grief, and loss. We briefly review the empirical research across a range of conditions which supports the use of MBIs for symptom and distress management, as well as their effects on stress and disease biomarkers that may play a role in the disease process. Recommendations for methodological …