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Monoamine releasers constitute a class of drugs that promote the release of dopamine (DA), serotonin (5‐HT) and/or norepinephrine. Although some drugs in this class are well‐known drugs of abuse (amphetamine, methamphetamine), others are thought to have reduced (3,4‐methylenedioxy‐N‐methylamphetamine [MDMA]) or no (fenfluramine) abuse potential. The purpose of this study was to further elucidate the role of dopamine versus serotonin selectivity on expression of abuse‐related effects produced by monoamine releasers in an assay of intracranial self‐stimulation (ICSS) in rats.

This study evaluated effects produced in a frequency–rate ICSS procedure by 11 monoamine releasers that vary in selectivity to release DA versus 5‐HT.

Efficacy of monoamine releasers to facilitate ICSS correlated with DA‐selectivity, such that DA‐selective …