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Monoamine releasers constitute one class of candidate medications for the treatment of cocaine abuse, and concurrent cocaine-versus-food choice procedures are potentially valuable as experimental tools to evaluate the efficacy and safety of candidate medications. This study assessed the choice between cocaine and food by rhesus monkeys during treatment with five monoamine releasers that varied in selectivity to promote the release of dopamine and norepinephrine versus serotonin (5HT)[m-fluoroamphetamine,(+)-phenmetrazine,(+)-methamphetamine, napthylisopropylamine and (±)-fenfluramine]. Rhesus monkeys (n= 8) responded under a concurrent-choice schedule of food delivery (1-g pellets, fixed ratio 100 schedule) and cocaine injections (0–0.1 mg/kg/injection, fixed ratio 10 schedule). Cocaine choice dose–effect curves were determined daily during continuous 7-day treatment with saline or with …