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Perfluorinated compounds are widely distributed in the environment; good knowledge about the toxic mode of action of these compounds can contribute to improved molecular design and risk assessment. The studied compounds were evaluated with a bacterial multiple endpoint reporter assay for responses in four different mode of action classes (oxidative damage, DNA damage, general cell lesions and membrane damage). The results of our study clearly demonstrate that inductions of stress responsive genes occur for the different compounds and confirm some of the known mechanisms of work for well studied compounds like PFOA and PFOS, and in addition provide new information for less studied compounds. Few inductions were observed after exposure to the low carbon number carboxylic acids, PFBtA (CF₃(CF₂)₂C(O)O⁻), PFPtA (CF₃(CF₂)₃C(O)O⁻), PFHxA (CF₃(CF₂)₄C(O)O⁻) and PFHpA (CF₃(CF₂)₅C …