查看文章

Exposure of red blood cells (RBCs) to catecholamines (epinephrine, phenylephrine, an agonist of α 1-adrenergic receptors, clonidine, an agonist of α 2-adrenergic receptors and isoproterenol, an agonist of β-adrenergic receptors) led to change in the RBC microrheological properties. When forskolin (10 μM), an AC stimulator was added to RBC suspension, the RBC deformability (RBCD) was increased by 17%(p< 0.05). Somewhat more significant deformability rise appeared after RBC incubation with dB-AMP (by 27%; p< 0.01). Red blood cell aggregation (RBCA) was significantly decreased under these conditions (p< 0.01). All drugs having PDE activity increased red cell deformability similarly. Some more changes of deformability was found after RBC incubation with pentoxifylline–25%(p< 0.05) and IBMX incubation was accompanied only by 15% rise of RBC deformability. The drugs with PDE inhibitory activity …