作者
Albert Wiegman, Samuel S Gidding, Gerald F Watts, M John Chapman, Henry N Ginsberg, Marina Cuchel, Leiv Ose, Maurizio Averna, Catherine Boileau, Jan Borén, Eric Bruckert, Alberico L Catapano, Joep C Defesche, Olivier S Descamps, Robert A Hegele, G Kees Hovingh, Steve E Humphries, Petri T Kovanen, Jan Albert Kuivenhoven, Luis Masana, Børge G Nordestgaard, Päivi Pajukanta, Klaus G Parhofer, Frederick J Raal, Kausik K Ray, Raul D Santos, Anton FH Stalenhoef, Elisabeth Steinhagen-Thiessen, Erik S Stroes, Marja-Riitta Taskinen, Anne Tybjærg-Hansen, Olov Wiklund, European Atherosclerosis Society Consensus Panel, Maurizio Averna, Catherine Boileau, Jan Borén, Eric Bruckert, Alberico L Catapano, M John Chapman, Marina Cuchel, Joep C Defesche, Olivier S Descamps, Samuel S Gidding, Henry N Ginsberg, Robert A Hegele, G Kees Hovingh, Steve E Humphries, Petri T Kovanen, Jan Albert Kuivenhoven, Luis Masana, Børge G Nordestgaard, Leiv Ose, Päivi Pajukanta, Klaus G Parhofer, Frederick J Raal, Kausik K Ray, Raul D Santos, Anton FH Stalenhoef, Elisabeth Steinhagen-Thiessen, Erik S Stroes, Marja-Riitta Taskinen, Anne Tybjærg-Hansen, Gerald F Watts, Albert Wiegman, Olov Wiklund, Samuel S Gidding, Gerald F Watts, M John Chapman, Henry N Ginsberg, Marina Cuchel, Leiv Ose, M John Chapman, Henry N Ginsberg
发表日期
2015/9/21
来源
European heart journal
卷号
36
期号
36
页码范围
2425-2437
出版商
Oxford University Press
简介
Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated early in childhood, individuals with FH can have normal life expectancy. This consensus paper aims to improve awareness of the need for early detection and management of FH children. Familial hypercholesterolaemia is diagnosed either on phenotypic criteria, i.e. an elevated low-density lipoprotein cholesterol (LDL-C) level plus a family history of elevated LDL-C, premature coronary artery disease and/or genetic diagnosis, or positive genetic testing. Childhood is the optimal period for discrimination between FH and non-FH using LDL-C screening. An LDL-C ≥5 mmol/L (190 mg/dL), or an LDL-C ≥4 mmol/L (160 mg/dL) with family history of premature CHD and/or high baseline cholesterol in one parent, make the phenotypic …
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A Wiegman, SS Gidding, GF Watts, MJ Chapman… - European heart journal, 2015