作者
Neha S Raghavan, Logan Dumitrescu, Elizabeth Mormino, Emily R Mahoney, Annie J Lee, Yizhe Gao, Murat Bilgel, David Goldstein, Theresa Harrison, Corinne D Engelman, Andrew J Saykin, Christopher D Whelan, Jimmy Z Liu, William Jagust, Marilyn Albert, Sterling C Johnson, Hyun-Sik Yang, Keith Johnson, Paul Aisen, Susan M Resnick, Reisa Sperling, Philip L De Jager, Julie Schneider, David A Bennett, Matthew Schrag, Badri Vardarajan, Timothy J Hohman, Richard Mayeux, Alzheimer’s Disease Neuroimaging Initiative
发表日期
2020/10/1
期刊
JAMA neurology
卷号
77
期号
10
页码范围
1288-1298
出版商
American Medical Association
简介
Importance
Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase of the disease.
Objective
To examine the underlying genetic basis for brain amyloidosis in the preclinical phase of Alzheimer disease.
Design, Setting, and Participants
In the first stage of this genetic association study, a meta-analysis was conducted using genetic and imaging data acquired from 6 multicenter cohort studies of healthy older individuals between 1994 and 2019: the Anti-Amyloid Treatment in Asymptomatic Alzheimer Disease Study, the Berkeley Aging Cohort Study, the Wisconsin Registry for Alzheimer’s Prevention, the Biomarkers of Cognitive Decline Among Normal Individuals cohort, the Baltimore Longitudinal Study of Aging, and the Alzheimer Disease Neuroimaging Initiative, which included Alzheimer …
学术搜索中的文章
NS Raghavan, L Dumitrescu, E Mormino, ER Mahoney… - JAMA neurology, 2020