作者
Yukio Ago, Michael C Condro, Yossan-Var Tan, Cristina A Ghiani, Christopher S Colwell, Jesse D Cushman, Michael S Fanselow, Hitoshi Hashimoto, James A Waschek
发表日期
2015/6
期刊
Psychopharmacology
卷号
232
页码范围
2181-2189
出版商
Springer Berlin Heidelberg
简介
Rationale
An abundance of genetic and epidemiologic evidence as well as longitudinal neuroimaging data point to developmental origins for schizophrenia and other mental health disorders. Recent clinical studies indicate that microduplications of VIPR2, encoding the vasoactive intestinal peptide (VIP) receptor VPAC2, confer significant risk for schizophrenia and autism spectrum disorder. Lymphocytes from patients with these mutations exhibited higher VIPR2 gene expression and VIP responsiveness (cAMP induction), but mechanisms by which overactive VPAC2 signaling may lead to these psychiatric disorders are unknown.
Objectives
We subcutaneously administered the highly selective VPAC2 receptor agonist Ro 25-1553 to C57BL/6 mice from postnatal day 1 (P1) to P14 to determine if overactivation of VPAC2 receptor signaling during postnatal …
学术搜索中的文章
Y Ago, MC Condro, YV Tan, CA Ghiani, CS Colwell… - Psychopharmacology, 2015