作者
Maria Juliana da L Froz, P Barros Luana de Souza, Ellen Nayara S de Jesus, Mateus S Tavares, Rosa Helena V Mourão, Renata Cunha Silva, Anderson B de Lima, Pedro Iuri C da Silva, Jofre Jacob S Freitas, William N Setzer, Joyce Kelly R da Silva, José Nazareno Cunha Negrão, Pablo Luis B Figueiredo
发表日期
2024/10/28
期刊
Journal of Ethnopharmacology
卷号
333
页码范围
118459
出版商
Elsevier
简介
Ethnopharmacological relevance
In Brazilian popular medicine, Lippia alba leaves are used in teas to treat pain and inflammatory diseases.
Aim of the study
to evaluate the chemical composition, antinociceptive, and anti-inflammatory activities of Lippia alba essential oil and its major compound geraniol.
Material and methods
Lippia alba leaves were collected in Pará state, Brazil. The leaf essential oil was obtained using a modified Clevenger-type extractor. Then, the oil was analyzed by GC and GC-MS analyses. To evaluate the toxicity of LaEO and geraniol, the doses of 50, 300, and 2000 mg/kg were used in a mouse model. For antinociception tests, abdominal contortion, hot plate, and formalin tests were used; all groups were treated with LaEO and geraniol at doses of 25, 50, and 100 mg/kg; and to evaluate inflammation using the ear edema model.
Results
The constituents identified in the highest content were …
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MJL Froz, PB Luana de Souza, ENS de Jesus… - Journal of Ethnopharmacology, 2024