作者
Amanda B Zheutlin, Jessica Dennis, Richard Karlsson Linnér, Arden Moscati, Nicole Restrepo, Peter Straub, Douglas Ruderfer, Victor M Castro, Chia-Yen Chen, Tian Ge, Laura M Huckins, Alexander Charney, H Lester Kirchner, Eli A Stahl, Christopher F Chabris, Lea K Davis, Jordan W Smoller
发表日期
2019/10/1
期刊
American Journal of Psychiatry
卷号
176
期号
10
页码范围
846-855
出版商
American Psychiatric Association
简介
Objective
Individuals at high risk for schizophrenia may benefit from early intervention, but few validated risk predictors are available. Genetic profiling is one approach to risk stratification that has been extensively validated in research cohorts. The authors sought to test the utility of this approach in clinical settings and to evaluate the broader health consequences of high genetic risk for schizophrenia.
Methods
The authors used electronic health records for 106,160 patients from four health care systems to evaluate the penetrance and pleiotropy of genetic risk for schizophrenia. Polygenic risk scores (PRSs) for schizophrenia were calculated from summary statistics and tested for association with 1,359 disease categories, including schizophrenia and psychosis, in phenome-wide association studies. Effects were combined through meta-analysis across sites.
Results
PRSs were robustly associated with schizophrenia …
学术搜索中的文章
AB Zheutlin, J Dennis, R Karlsson Linnér, A Moscati… - American Journal of Psychiatry, 2019
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