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In recent decades, dietary manipulation has been one of the strategies to solve health problems, since nutraceuticals, natural products, extracts and bioactives have been used with a therapeutic approach. Among the bioactives are curcumin, with a high antioxidant and anti-inflammatory power, and capsaicin, which favors its uptake after oral ingestion. However, both have low aqueous solubility, a feature that makes it difficult to use them in clinical trials, and oral bioavailability, indicating a small use. To circumvent these problems, incorporating them into solid lipid nanoparticle (SLN) may allow for more efficient delivery. The development and application of new nanotechnological products are increasing in the pharmaceutical and medical areas, especially pharmaceutical nanocarriers. Given this context, this thesis is original and innovative because, for the first time, an SLN containing curcumin and capsaicin (NCC …