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BACKGROUND: In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown. AIM: The objective of this study was to explore the involvement of monoamines in the antidepressant-like effect of AECSF in mice. MATERIALS AND METHODS: AECSF was prepared by steaming the fillets of C. striatus. The male ICR mice were pretreated with various monoaminergic antagonists viz., p-chlorophenylalanine (100 mg/kg, ip), prazosin (1 mg/kg, ip) and yohimbine (1 mg/kg, ip), SCH23390 (0.05 mg/kg, sc) and sulpiride (50 mg/kg, ip) followed by treatment with AECSF and tested in tail suspension test (TST). Two-way ANOVA with Tukey test were used at p < 0.05 for significance. RESUL TS: The pretreatments with p-chlorophenylalanine, prazosin and yohimbine, but not with …