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This study provides a first test of an experimental method, the “space odyssey” paradigm, that was designed to manipulate interpretation bias in children. Seventy non-clinical children aged 8–12 years first completed a standardized anxiety questionnaire. Following this, they completed the space odyssey paradigm to induce either a negative or a positive interpretation bias. After this stage of interpretation training, children were presented with a series of ambiguous vignettes for which they had to rate perceived levels of threat as an index of interpretation bias. Results indicated that the space odyssey paradigm was successful in training interpretations: children in the negative training condition quickly learned to choose negative outcomes, while children in the positive training condition rapidly learned to select positive outcomes. Most importantly, children’s subsequent threat perception scores for the …