作者
Hong-rou Lin, Fengzhe Xu, Danyu Chen, Keliang Xie, Yingdi Yang, Wei Hu, Bang-yan Li, Zengliang Jiang, Yuhui Liang, Xin-yi Tang, Ju-Sheng Zheng, Yu-ming Chen
发表日期
2023/6/1
期刊
Clinical Nutrition
卷号
42
期号
6
页码范围
887-898
出版商
Churchill Livingstone
简介
Background & aims
Previous studies have suggested that circulating 25-hydroxyvitamin D (25 [OH]D, VD) and the gut microbiota-bile acid axis play crucial roles in metabolic health. Exploring the mediating role of the gut microbiota-bile acid axis would improve our understanding of the mechanisms underlying the effects of VD on human metabolic health. This study examined the association between plasma 25(OH)D and the prevalence/incidence of metabolic syndrome (MetS) and the mediating role of the gut microbiota-bile acid axis.
Methods
This prospective study included 3180 participants with plasma 25(OH)D data at baseline and 2966 participants with a 9-year follow-up. MetS was determined every three years. The gut microbiota was analyzed by 16S rRNA sequencing in 1752 participants, and targeted bile acid metabolites in feces were further determined in 974 participants using UPLC‒MS/MS at the …
学术搜索中的文章
H Lin, F Xu, D Chen, K Xie, Y Yang, W Hu, B Li, Z Jiang… - Clinical Nutrition, 2023