作者
Francesca Panico, Christian Casali, Giulio Rossi, Federica Rizzi, Uliano Morandi, Saverio Bettuzzi, Pierpaola Davalli, Lorenzo Corbetta, Erica Susanna Storelli, Arnaldo Corti, Leonardo M Fabbri, Serenella Astancolle, Fabrizio Luppi
发表日期
2013/3/1
期刊
Lung Cancer
卷号
79
期号
3
页码范围
294-299
出版商
Elsevier
简介
RATIONALE
Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30–50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung.
OBJECTIVES
We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung.
FINDINGS
The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate …
学术搜索中的文章
F Panico, C Casali, G Rossi, F Rizzi, U Morandi… - Lung Cancer, 2013