作者
Tatiana H Rech, Rafael B Moraes, Daisy Crispim, Mauro A Czepielewski, Cristiane B Leitao
发表日期
2013/4/15
来源
Transplantation
卷号
95
期号
7
页码范围
966-974
出版商
LWW
简介
Background
The shortage of organs is a limitation for transplantation, making the care of potential organ donors an important issue. The present systematic review and meta-analysis was carried out to assess the efficacy of interventions to stabilize hemodynamics in brain-dead donors or to improve organ function and outcomes of transplantation.
Methods
Medline, Embase, and Cochrane databases were searched. Of 5096 articles retrieved, 39 randomized controlled trials were selected. Twenty were included in a qualitative synthesis, providing data on 1277 patients. The main interventions described were desmopressin use, triiodothyronine and methylprednisolone replacement, fluid management, vasopressor therapy, mechanical ventilation strategies, and surgical techniques.
Results
Three meta-analyses were conducted: the first included two studies and showed that desmopressin administered to brain-dead …
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TH Rech, RB Moraes, D Crispim, MA Czepielewski… - Transplantation, 2013