作者
Maria Siopi, Nikolaos Siafakas, Sophia Vourli, Loukia Zerva, Joseph Meletiadis
发表日期
2015/7
期刊
Antimicrobial Agents and Chemotherapy
卷号
59
期号
7
页码范围
3973-3983
出版商
American Society for Microbiology
简介
Although amphotericin B-azole combination therapy has traditionally been questioned due to potential antagonistic interactions, it is often used successfully to treat refractory invasive aspergillosis. So far, pharmacodynamic (PD) interactions have been assessed with conventional in vitro tests, which do not mimic human serum concentrations and animal models using limited doses. We therefore simulated the human serum concentration profiles of amphotericin B and voriconazole in an in vitro dialysis/diffusion closed pharmacokinetic-pharmacodynamic (PK-PD) model and studied the pharmacodynamic interactions against an azole-resistant and an azole-susceptible Aspergillus fumigatus isolate, using Bliss independence and canonical mixture response surface analyses. Amphotericin B dosing regimens with the drug administered every 24 h (q24h) were combined with voriconazole q12h dosing regimens. In …
学术搜索中的文章
M Siopi, N Siafakas, S Vourli, L Zerva, J Meletiadis - Antimicrobial Agents and Chemotherapy, 2015