作者
Paul Castillo, Elizabeth Ogando-Rivas, Hillary Geffrard, Alfonso Pepe, Ruixuan Liu, Duy Nguyen, Diego Pedro, Dingpeng Zhang, Anna DeVries, Sadeem Qdaisat, Adam Grippin, Aida Karachi, Maryam Rahman, Rowan Milner, Jianping Huang, John Ligon, Natalie Silver, Derek Li, Ji-Hyun Lee, Sheila Carrera-Justiz, Frances Weidert, Duane Mitchell, Hector Mendez-Gomez, W Gregory Sawyer, Elias Sayour
发表日期
2023/11/1
期刊
Neuro-Oncology
卷号
25
期号
Supplement_5
页码范围
v145-v146
出版商
Oxford University Press
简介
BACKGROUND
Pathogen recognition receptor (PRR) activation is requisite for igniting the immune response and making the tumor microenvironment ‘hot’ during oncogenesis. We theorized that these PRRs would remain present in ICI responsive tumors and could be challenged using pan-PRR mimic to prospectively predict brain cancer immunogenicity and response to immune checkpoint inhibitors (ICIs).
METHODS
By layering mRNA into multilamellar nanoparticles (ML RNA-NPs), multiple pathogen recognition receptors can be simultaneously activated in individualized cancer cells serving as a broad screen to test tumor immunogenicity. We challenged murine brain tumor lines known to respond (GL261 and SMA-560) or resist ICI treatment (KR158b and CT2A) with ML RNA-NPs and analyzed downstream production of proinflammatory cytokines as predictors of ICI …
学术搜索中的文章
P Castillo, E Ogando-Rivas, H Geffrard, A Pepe, R Liu… - Neuro-Oncology, 2023