作者
Troy S Wildes, Angela M Mickle, Arbi Ben Abdallah, Hannah R Maybrier, Jordan Oberhaus, Thaddeus P Budelier, Alex Kronzer, Sherry L McKinnon, Daniel Park, Brian A Torres, Thomas J Graetz, Daniel A Emmert, Ben J Palanca, Shreya Goswami, Katherine Jordan, Nan Lin, Bradley A Fritz, Tracey W Stevens, Eric Jacobsohn, Eva M Schmitt, Sharon K Inouye, Susan Stark, Eric J Lenze, Michael S Avidan, ENGAGES Research Group
发表日期
2019/2/5
期刊
Jama
卷号
321
期号
5
页码范围
473-483
出版商
American Medical Association
简介
Importance
Intraoperative electroencephalogram (EEG) waveform suppression, often suggesting excessive general anesthesia, has been associated with postoperative delirium.
Objective
To assess whether EEG-guided anesthetic administration decreases the incidence of postoperative delirium.
Design, Setting, and Participants
Randomized clinical trial of 1232 adults aged 60 years and older undergoing major surgery and receiving general anesthesia at Barnes-Jewish Hospital in St Louis. Recruitment was from January 2015 to May 2018, with follow-up until July 2018.
Interventions
Patients were randomized 1:1 (stratified by cardiac vs noncardiac surgery and positive vs negative recent fall history) to receive EEG-guided anesthetic administration (n = 614) or usual anesthetic care (n = 618).
Main Outcomes and Measures
The primary outcome was incident delirium during postoperative days 1 through 5 …
学术搜索中的文章
TS Wildes, AM Mickle, AB Abdallah, HR Maybrier… - Jama, 2019