作者
George A Mashour, Amy Shanks, Kevin K Tremper, Sachin Kheterpal, Christopher R Turner, Satya Krishna Ramachandran, Paul Picton, Christa Schueller, Michelle Morris, John C Vandervest, Nan Lin, Michael S Avidan
发表日期
2012/10/1
期刊
The Journal of the American Society of Anesthesiologists
卷号
117
期号
4
页码范围
717-725
出版商
The American Society of Anesthesiologists
简介
Background
Intraoperative awareness with explicit recall occurs in approximately 0.15% of all surgical cases. Efficacy trials based on the Bispectral Index® (BIS) monitor (Covidien, Boulder, CO) and anesthetic concentrations have focused on high-risk patients, but there are no effectiveness data applicable to an unselected surgical population.
Methods
We conducted a randomized controlled trial of unselected surgical patients at three hospitals of a tertiary academic medical center. Surgical cases were randomized to alerting algorithms based on either BIS values or anesthetic concentrations. The primary outcome was the incidence of definite intraoperative awareness; prespecified secondary outcomes included postanesthetic recovery variables.
Results
The study was terminated because of futility. At interim analysis the incidence of definite awareness was 0 …
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