作者
Michael S Avidan, Hannah R Maybrier, Arbi Ben Abdallah, Eric Jacobsohn, Phillip E Vlisides, Kane O Pryor, Robert A Veselis, Hilary P Grocott, Daniel A Emmert, Emma M Rogers, Robert J Downey, Heidi Yulico, Gyu-Jeong Noh, Yonghun H Lee, Christine M Waszynski, Virendra K Arya, Paul S Pagel, Judith A Hudetz, Maxwell R Muench, Bradley A Fritz, Witold Waberski, Sharon K Inouye, George A Mashour, Ginika P Apakama, Karen G Aquino, Robert S Dicks, Krisztina E Escallier, Hussein Fardous, Duane J Funk, Keith E Gipson, Leonard N Girardi, Hillary Grocott, Alison T Gruber, Natalia S Ivascu, Aveek Jayant, Hessam H Kashani, Morvarid S Kavosh, Bryan S Kunkler, Yonghun Lee, Eric J Lenze, Amy S McKinney, Sherry L McKinnon, Angela M Mickle, Marita Monterola, Matthew R Murphy, Mariya Redko, Eva M Schmitt, Lingesh Sivanesan, Michele L Steinkamp, Bethany Tellor, Sunu Thomas, Ravi T Upadhyayula, Philip E Vlisides, Christine Waszynski
发表日期
2017/7/15
期刊
The Lancet
卷号
390
期号
10091
页码范围
267-275
出版商
Elsevier
简介
Background
Delirium is a common and serious postoperative complication. Subanaesthetic ketamine is often administered intraoperatively for postoperative analgesia, and some evidence suggests that ketamine prevents delirium. The primary purpose of this trial was to assess the effectiveness of ketamine for prevention of postoperative delirium in older adults.
Methods
The Prevention of Delirium and Complications Associated with Surgical Treatments [PODCAST] study is a multicentre, international randomised trial that enrolled adults older than 60 years undergoing major cardiac and non-cardiac surgery under general anaesthesia. Using a computer-generated randomisation sequence we randomly assigned patients to one of three groups in blocks of 15 to receive placebo (normal saline), low-dose ketamine (0·5 mg/kg), or high dose ketamine (1·0 mg/kg) after induction of anaesthesia, before surgical incision …
学术搜索中的文章
MS Avidan, HR Maybrier, AB Abdallah, E Jacobsohn… - The Lancet, 2017