作者
Gregoire Boulouis, Andreas Charidimou, Marco Pasi, Duangnapa Roongpiboonsopit, Li Xiong, Eitan Auriel, Ellis S van Etten, Sergi Martinez-Ramirez, Alison Ayres, Anastasia Vashkevich, Kristin M Schwab, Jonathan Rosand, Joshua N Goldstein, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
发表日期
2017/9/15
期刊
Journal of the neurological sciences
卷号
380
页码范围
64-67
出版商
Elsevier
简介
Introduction
An MRI-based score of total small vessel disease burden (CAA-SVD-Score) in cerebral amyloid angiopathy (CAA) has been demonstrated to correlate with severity of pathologic changes. Evidence suggests that CAA-related intracerebral hemorrhage (ICH) recurrence risk is associated with specific disease imaging manifestations rather than overall severity. We compared the correlation between the CAA-SVD-Score with the risk of recurrent CAA-related lobar ICH versus the predictive role of each of its components.
Methods
Consecutive patients with CAA-related ICH from a single-center prospective cohort were analyzed. Radiological markers of CAA related SVD damage were quantified and categorized according to the CAA-SVD-Score (0–6 points).
Subjects were followed prospectively for recurrent symptomatic ICH. Adjusted Cox proportional hazards models were used to investigate associations …
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G Boulouis, A Charidimou, M Pasi… - Journal of the neurological sciences, 2017