作者
Jingwei Wei, Guoqiang Yang, Xiaohan Hao, Dongsheng Gu, Yan Tan, Xiaochun Wang, Di Dong, Shuaitong Zhang, Le Wang, Hui Zhang, Jie Tian
发表日期
2019/2
期刊
European radiology
卷号
29
页码范围
877-888
出版商
Springer Berlin Heidelberg
简介
Objectives
Oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a significant prognostic biomarker in astrocytomas, especially for temozolomide (TMZ) chemotherapy. This study aimed to preoperatively predict MGMT methylation status based on magnetic resonance imaging (MRI) radiomics and validate its value for evaluation of TMZ chemotherapy effect.
Methods
We retrospectively reviewed a cohort of 105 patients with grade II-IV astrocytomas. Radiomic features were extracted from the tumour and peritumoral oedema habitats on contrast-enhanced T1-weighted images, T2-weighted fluid-attenuated inversion recovery images and apparent diffusion coefficient (ADC) maps. The following radiomics analysis was structured in three phases: feature reduction, signature construction and discrimination statistics. A fusion …
学术搜索中的文章
J Wei, G Yang, X Hao, D Gu, Y Tan, X Wang, D Dong… - European radiology, 2019