作者
MT Mackay, SK Weiss, T Adams-Webber, S Ashwal, D Stephens, K Ballaban-Gill, TZ Baram, M Duchowny, D Hirtz, JM Pellock, WD Shields, S Shinnar, E Wyllie, OC Snead III
发表日期
2004/5/25
来源
Neurology
卷号
62
期号
10
页码范围
1668-1681
出版商
Lippincott Williams & Wilkins
简介
Objective: To determine the current best practice for treatment of infantile spasms in children.
Methods: Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference lists of retrieved articles were performed. Inclusion criteria were the documented presence of infantile spasms and hypsarrhythmia. Outcome measures included complete cessation of spasms, resolution of hypsarrhythmia, relapse rate, developmental outcome, and presence or absence of epilepsy or an epileptiform EEG. One hundred fifty-nine articles were selected for detailed review. Recommendations were based on a four-tiered classification scheme.
Results: Adrenocorticotropic hormone (ACTH) is probably effective for the short-term treatment of infantile spasms, but there is insufficient evidence to recommend the optimum dosage and duration of treatment. There is insufficient evidence to determine …
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