作者
Caleb Ing, Charles DiMaggio, Andrew Whitehouse, Mary K Hegarty, Joanne Brady, Britta S von Ungern-Sternberg, Andrew Davidson, Alastair JJ Wood, Guohua Li, Lena S Sun
发表日期
2012/9/1
期刊
Pediatrics
卷号
130
期号
3
页码范围
e476-e485
出版商
American Academy of Pediatrics
简介
BACKGROUND
Over the past decade, the safety of anesthetic agents in children has been questioned after the discovery that immature animals exposed to anesthesia display apoptotic neurodegeneration and long-term cognitive deficiencies. We examined the association between exposure to anesthesia in children under age 3 and outcomes in language, cognitive function, motor skills, and behavior at age 10.
METHODS
We performed an analysis of the Western Australian Pregnancy Cohort (Raine) Study, which includes 2868 children born from 1989 to 1992. Of 2608 children assessed, 321 were exposed to anesthesia before age 3, and 2287 were unexposed.
RESULTS
On average, exposed children had lower scores than their unexposed peers in receptive and expressive language (Clinical Evaluation of Language Fundamentals: Receptive [CELF-R] and Expressive [CELF-E]) and cognition (Colored …
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C Ing, C DiMaggio, A Whitehouse, MK Hegarty, J Brady… - Pediatrics, 2012