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Background. Currently, a novel coronavirus found in 2019 known as SARS‐CoV‐2 is the etiological agent of the COVID‐19 pandemic. Various parameters including clinical manifestations and molecular evaluation can affect the accuracy of diagnosis. This review aims to discuss the various clinical symptoms and molecular evaluation results in COVID‐19 patients, to point out the importance of onset symptoms, type, and timing of the sampling, besides the methods that are used for detection of SARS‐CoV‐2. Methods. A systematic literature review of current articles in the Web of Science, PubMed, Scopus, and EMBASE was conducted according to the PRISMA guideline. Results. Of the 12946 patients evaluated in this investigation, 7643 were confirmed to be COVID‐19 positive by molecular techniques, particularly the RT‐PCR/qPCR combined technique (qRT‐PCR). In most of the studies, all of the enrolled cases …