作者
William L Baker, Ripple Talati, C Michael White, Craig I Coleman
发表日期
2010/1/1
来源
Diabetes research and clinical practice
卷号
87
期号
1
页码范围
98-107
出版商
Elsevier
简介
BACKGROUND
To determine whether individual statins had differing effects on insulin sensitivity (IS) in patients without pre-existing diabetes mellitus.
METHODS
A systematic literature search of MEDLINE, EMBASE and Cochrane CENTRAL was conducted through December 2008. Trials were included if they compared pravastatin, atorvastatin, rosuvastatin or simvastatin to placebo/control, excluded patients with diabetes, and reported data on insulin sensitivity/resistance. IS data was pooled and evaluated as standardized mean differences (SMDs) and 95% confidence interval (CI) using a random-effects model.
RESULTS
16 studies (n=1146) were included, with patients receiving pravastatin in three trials (n=164), atorvastatin in five trials (n=315), rosuvastatin in five trials (n=419), and simvastatin in five trials (n=369). When pooled as a class, statins had no significant impact on IS as compared with placebo …
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WL Baker, R Talati, CM White, CI Coleman - Diabetes research and clinical practice, 2010