作者
Yanchun Peng, Suet Ling Felce, Danning Dong, Frank Penkava, Alexander J Mentzer, Xuan Yao, Guihai Liu, Zixi Yin, Ji-Li Chen, Yongxu Lu, Dannielle Wellington, Peter AC Wing, Delaney CC Dominey-Foy, Chen Jin, Wenbo Wang, Megat Abd Hamid, Ricardo A Fernandes, Beibei Wang, Anastasia Fries, Xiaodong Zhuang, Neil Ashley, Timothy Rostron, Craig Waugh, Paul Sopp, Philip Hublitz, Ryan Beveridge, Tiong Kit Tan, Christina Dold, Andrew J Kwok, Charlotte Rich-Griffin, Wanwisa Dejnirattisa, Chang Liu, Prathiba Kurupati, Isar Nassiri, Robert A Watson, Orion Tong, Chelsea A Taylor, Piyush Kumar Sharma, Bo Sun, Fabiola Curion, Santiago Revale, Lucy C Garner, Kathrin Jansen, Ricardo C Ferreira, Moustafa Attar, Jeremy W Fry, Rebecca A Russell, COMBAT Consortium, Hans J Stauss, William James, Alain Townsend, Ling-Pei Ho, Paul Klenerman, Juthathip Mongkolsapaya, Gavin R Screaton, Calliope Dendrou, Stephen N Sansom, Rachael Bashford-Rogers, Benny Chain, Geoffrey L Smith, Jane A McKeating, Benjamin P Fairfax, Paul Bowness, Andrew J McMichael, Graham Ogg, Julian C Knight, Tao Dong
发表日期
2022/1
期刊
Nature immunology
卷号
23
期号
1
页码范围
50-61
出版商
Nature Publishing Group US
简介
NP105–113-B*07:02-specific CD8+ T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP105–113-B*07:02-specific T cell clones and single-cell sequencing were performed concurrently, with functional avidity and antiviral efficacy assessed using an in vitro SARS-CoV-2 infection system, and were correlated with T cell receptor usage, transcriptome signature and disease severity (acute n = 77, convalescent n = 52). We demonstrated a beneficial association of NP105–113-B*07:02-specific T cells in COVID-19 disease progression, linked with expansion of T cell precursors, high functional avidity and antiviral effector function. Broad immune memory pools were narrowed postinfection but NP105–113-B*07:02-specific T cells were maintained 6 months after infection with preserved antiviral …
学术搜索中的文章
Y Peng, SL Felce, D Dong, F Penkava, AJ Mentzer… - Nature immunology, 2022