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Inspired by the rich diversity of non-covalent interactions occurring in nature, researchers have pursued artificial receptors preparation by molecular imprinting technology. Recognition sites in molecularly imprinted polymers (MIPs), in case of non-covalent approach, are created by the polymerization of preorganized functional monomers around the template with weak interactions, leading to broad distribution of specific binding sites. The metal-coordination interactions are quite directional, therefore very promising to MIPs design. The well defined coordination sphere of many transition metals complexes allows control of the orientation of functionality in MIPs, offering a high degree of versatility in targeting different functional groups in many biologically molecules. The production of MIPs for the recognition of C-terminal cholecystokinin pentapeptide (CCK-5, NH2-Gly-Trp-Met-Asp-Phe-CONH2) in the presence of …