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Introduction: Studies of hospital information systems have been affected to reduce costs and boost the quality of care. In the present study, affective factors related to the knowledge of radiology department staffs have been investigated about the applications of hospital information system.

Methods and Materials: Descriptive analytic method has been conducted in the current study. Staffs of six hospital of Kermanshah were participated in this study in 2015. A questionnaire included two sections of demographic and 40 questions related to the knowledge that have been used to assess the knowledge and its affective factors. The validity of the questionnaire was confirmed by the related expert and the reliability was gained 80% by Cronbach’s alpha. Data analyses were performed using STATA software package version 12; moreover, linear regression was used to assess the impact of variables under study on employers’ knowledge. Results: The samples of this study were 76 females and 50 males that most of them have associate degree (47.6%). Mean level of knowledge of those passed the course HIS was higher (26.65) than those did not passed the course (22.93). The highest scores were observed in those with master’s degree (30.8). The results indicated that there is a significant relationship between the training HIS, having degree such as bachelor, masters, or higher than masters, and working with the imaging systems with the staff’s score knowledge (p< 0.05). Discussion and Conclusion: Based on the fact that using hospital information systems will decrease costs and increase the quality of caring about there is a need for authorities …