作者
Cornelia GF van Lanschot, Yoram P Klazen, Maria AJ de Ridder, Hetty Mast, Ivo Ten Hove, José A Hardillo, Dominiek A Monserez, Aniel Sewnaik, Cees A Meeuwis, Stijn Keereweer, Yassine Aaboubout, Elisa M Barroso, Quincy M van der Toom, Tom C Bakker Schut, Eppo B Wolvius, Robert J Baatenburg de Jong, Gerwin J Puppels, Senada Koljenović
发表日期
2020/12/1
期刊
Oral Oncology
卷号
111
页码范围
104940
出版商
Pergamon
简介
Objectives
Depth of invasion (DOI) is the most important predictor for lymph node metastasis (LNM) in early stage (T1-T2) oral cancer. The aim of this study is to validate the cut-off value of 4 mm on which the decision to perform an Elective Neck Dissection (END) is made.
Materials and methods
We performed a retrospective study in patients with pathologically proven early stage oral cavity squamous cell carcinoma (OCSCC) without clinical or radiological signs of LNM, who were treated between 2013 and 2018. An END was performed when DOI was ≥ 4 mm and a watchful waiting protocol was applied in patients with DOI < 4 mm.
Results
Three hundred patients were included. END was performed in 77% of patients with DOI ≥ 4 mm, of which 36% had occult LNM (pN+). Patients in the watchful waiting group (48%) developed a regional recurrence in 5.2% for DOI < 4 mm and 24.1% for DOI ≥ 4 mm. For DOI ≥ 4 …
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CGF van Lanschot, YP Klazen, MAJ de Ridder, H Mast… - Oral Oncology, 2020