作者
PBAA Van Driel, Martijn van de Giessen, MC Boonstra, TJA Snoeks, Stijn Keereweer, Sabrina Oliveira, CJH Van De Velde, BPF Lelieveldt, AL Vahrmeijer, CWGM Löwik, Jouke Dijkstra
发表日期
2015/6
期刊
Molecular Imaging and Biology
卷号
17
页码范围
413-423
出版商
Springer US
简介
Purpose
Near-infrared (NIR) fluorescence imaging can provide the surgeon with real-time visualization of, e.g., tumor margins and lymph nodes. We describe and evaluate the Artemis, a novel, handheld NIR fluorescence camera.
Procedures
We evaluated minimal detectable cell numbers (FaDu-luc2, 7D12-IRDye 800CW), preclinical intraoperative detection of sentinel lymph nodes (SLN) using indocyanine green (ICG), and of orthotopic tongue tumors using 7D12-800CW. Results were compared with the Pearl imager. Clinically, three patients with liver metastases were imaged using ICG.
Results
Minimum detectable cell counts for Artemis and Pearl were 2 × 105 and 4 × 104 cells, respectively. In vivo, seven SLNs were detected in four mice with both cameras. Orthotopic OSC-19-luc2-cGFP tongue tumors were …
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P Van Driel, M van de Giessen, MC Boonstra… - Molecular Imaging and Biology, 2015