作者
Mohamed Hashem, Ravi Jhaveri, Doa’a A Saleh, Sahar A Sharaf, Fatma El-Mougy, Lobna Abdelsalam, Michelle D Shardell, Hesham El-Ghazaly, Samer S El-Kamary
发表日期
2017/9/15
期刊
Clinical Infectious Diseases
卷号
65
期号
6
页码范围
999-1005
出版商
Oxford University Press
简介
Background
Postpartum hepatitis C viral (HCV) load decline followed by spontaneous clearance has been previously described. Herein we identify predictors for viral decline in a cohort of HCV-infected postpartum women.
Methods
Pregnant women at Cairo University were screened for anti-HCV antibodies and HCV RNA, and viremic women were tested for quantitative HCV RNA at 3, 6, 9, and 12 months postpartum. Spontaneous clearance was defined as undetectable viremia twice at least 6-months apart. Associations between viral load and demographic, obstetrical, HCV risk factors, and interleukin-28B gene (IL28B) polymorphism (rs12979860) were assessed.
Results
Of 2514 women, 97 (3.9%) had anti-HCV antibodies, 54 (2.1%) were viremic and of those, 52 (2.1%) agreed to IL28B testing. From pregnancy until 12 months postpartum, IL28B-CC …
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M Hashem, R Jhaveri, DA Saleh, SA Sharaf… - Clinical Infectious Diseases, 2017