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To compare the efficacy and safety of subthreshold micropulse laser treatment (SML), standard-fluence photodynamic therapy (PDT) and low-fluence PDT in patients with chronic central serous chorioretinopathy (cCSC).

This retrospective study included 52 eyes of 46 patients with chronic CSC who were treated with 577 nm SML (n = 23), standard-fluence PDT (verteporfin 6 mg/m² and light energy 50 J/cm²) (n = 13), or low-fluence PDT (verteporfin 6 mg/m² and light energy 25 J/cm²) (n = 16). The mean changes in best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) parameters, including central retinal thickness (CRT), subretinal fluid (SRF) height, and ellipsoid zone (EZ) disruption, over the follow-up period were evaluated.

The mean follow-up period was 8.42 ± 3.34 months. In the SML group, the SRF resolution time was longer than the other groups. At 1 month …