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Rationale: The relationship between unexplained or refractory chronic cough (URCC) and mental health disorders (MHD) is not well understood. Therefore, we aimed to review the clinical characteristics of URCC patients with and without anxiety and/or depression, as well as patient outcomes on pregabalin therapy.

Methods: 50 consecutive URCC patients at Montfort Hospital (Canada) were assessed; half had a diagnosis of anxiety and/or depression. Patients were prescribed pregabalin 75 mg oral qhs for 4 weeks, followed by 75 mg bid. We reviewed demographic data, medical diagnoses, prior cigarette smoking, and cough duration. Leicester Cough Questionnaire (LCQ) was completed at baseline and after 3 months of therapy. T-test and chi-square test were performed for the comparison of clinical characteristics and responses to pregabalin.

Results: 33 patients were female; mean age was 63 years. Mean BMI …