作者
Mathieu Saint-Pierre, Jamil Ladha, Danilo Berton, Angie Zapotichny, Denis Faubert, Lori Crozier-Wells, Julianna Tang, Cathy Muir, Lutz Forkert, Denis O'Donnell, Jose Alberto Neder Serafini
发表日期
2016/9/1
来源
European Respiratory Journal
卷号
48
期号
suppl 60
出版商
European Respiratory Society
简介
Background: Forced vital capacity (FVC) may substantially underestimate slow expiratory VC (SVC) in patients with airflow obstruction thereby leading to a “pseudo-normal” FEV1/FVC (i.e., ≥ 0.7 and/or ≥ lower limit of normality (LLN)). It remains unclear in which specific circumstances FEV1/SVC would be helpful to uncover airway obstruction despite preserved FEV1/FVC.
Methods: 15,801 consecutive spirometric measurements showing pre-bronchodilator FEV1/SVC < 0.7 and/or <LLN.
Results: Twenty percent (3,031/15,801) of subjects with FEV1/SVC < 0.7 had FEV1/FVC ≥ 0.7. Among those presenting with both ratios < 0.7, 51.8% had FEV1/SVC < LLN but FEV1/FVC ≥ LLN. Most patients diagnosed with airflow obstruction only by FEV1/SVC had mild disease. However, they did present with lower FEF25-75%, higher residual volume and higher specific airway resistance than those with preserved FEV1/FVC (p …
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M Saint-Pierre, J Ladha, D Berton, A Zapotichny… - 2016