作者
Joshua J Obar, Leo Lefrançois
发表日期
2010/8/1
来源
International immunology
卷号
22
期号
8
页码范围
619-625
出版商
Oxford University Press
简介
Understanding the regulation of the CD8+ T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8+ T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8+ T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8+ T cells.
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JJ Obar, L Lefrançois - International immunology, 2010