作者
Jessica L Castilho, Aihua Bian, Cathy A Jenkins, Bryan E Shepherd, Keith Sigel, M John Gill, Mari M Kitahata, Michael J Silverberg, Angel M Mayor, Sally B Coburn, Dorothy Wiley, Chad J Achenbach, Vincent C Marconi, Ronald J Bosch, Michael A Horberg, Charles S Rabkin, Sonia Napravnik, Richard M Novak, W Christopher Mathews, Jennifer E Thorne, Jing Sun, Keri N Althoff, Richard D Moore, Timothy R Sterling, Staci L Sudenga
发表日期
2022/6
期刊
JNCI: Journal of the National Cancer Institute
卷号
114
期号
6
页码范围
854-862
出版商
Oxford University Press
简介
Background
Independent of CD4 cell count, a low CD4/CD8 ratio in people with HIV (PWH) is associated with deleterious immune senescence, activation, and inflammation, which may contribute to carcinogenesis and excess cancer risk. We examined whether low CD4/CD8 ratios predicted cancer among PWH in the United States and Canada.
Methods
We examined all cancer-free PWH with 1 or more CD4/CD8 values from North American AIDS Cohort Collaboration on Research and Design observational cohorts with validated cancer diagnoses between 1998 and 2016. We evaluated the association between time-lagged CD4/CD8 ratio and risk of specific cancers in multivariable, time-updated Cox proportional hazard models using restricted cubic spines. Models were adjusted for age, sex, race and ethnicity, hepatitis C virus, and time-updated CD4 cell count, HIV RNA …
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JL Castilho, A Bian, CA Jenkins, BE Shepherd, K Sigel… - JNCI: Journal of the National Cancer Institute, 2022