作者
Britton Trabert, Sally B Coburn, Roni T Falk, JoAnn E Manson, Louise A Brinton, Margery L Gass, Lewis H Kuller, Thomas E Rohan, Ruth M Pfeiffer, Lihong Qi, Marcia L Stefanick, Nicolas Wentzensen, Garnet L Anderson, Xia Xu
发表日期
2019/11
期刊
Cancer Causes & Control
卷号
30
页码范围
1201-1211
出版商
Springer International Publishing
简介
Purpose
Menopausal hormone therapy (MHT) use induces alterations in circulating estrogens/estrogen metabolites, which may contribute to the altered risk of reproductive tract cancers among current users. Thus, the current study assessed associations between circulating estrogens/estrogen metabolites and ovarian and endometrial cancer risk among MHT users.
Methods
We conducted a nested case–control study among postmenopausal women using MHT at baseline in the Women’s Health Initiative Observational Study (179 ovarian cancers, 396 controls; 230 endometrial cancers, 253 controls). Multivariable logistic regression was utilized to estimate odds ratios and 95% confidence intervals overall and by subtype.
Results
Estrogen/estrogen metabolite levels were not associated with overall or serous ovarian …
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