作者
Ana I Matos, Barbara Carreira, Carina Peres, Liane IF Moura, João Conniot, Thibaut Fourniols, Anna Scomparin, Águeda Martínez-Barriocanal, Diego Arango, João P Conde, Véronique Préat, Ronit Satchi-Fainaro, Helena F Florindo
发表日期
2019/8/10
来源
Journal of Controlled Release
卷号
307
页码范围
108-138
出版商
Elsevier
简介
Colorectal cancer (CRC) is among the five most commonly diagnosed cancers worldwide, constituting 6% of all cancers and the third leading cause of cancer death. CRC is the third and second most frequent cancer in men and women worldwide, accounting for 14% and 13% of all cancer incidence rates, respectively. CRC incidence is decreasing in older populations, but it has been significantly rising worldwide in adolescents and adults younger than 50 years old.
Significant advances in the screening methods and surgical procedures have been underlying the reduction of the CRC incidence rate in older populations. However, there is an urgent demand for the development of alternative effective therapeutic options to overcome advanced metastatic CRC, while preventing disease recurrence.
This review addresses the immune and CRC biology, summarizing the recent advances on the immune and/or …
学术搜索中的文章
AI Matos, B Carreira, C Peres, LIF Moura, J Conniot… - Journal of Controlled Release, 2019