作者
Nedal Taha, George F Araj, Rima H Wakim, Souha S Kanj, Zeina A Kanafani, Ahmad Sabra, Marie-Therese Khairallah, Farah J Nassar, Marwa Shehab, Maysa Baroud, Ghassan Dbaibo, Ghassan M Matar
发表日期
2012/1
期刊
Annals of clinical microbiology and antimicrobials
卷号
11
页码范围
1-6
出版商
BioMed Central
简介
Background
This study determined macrolide resistance genotypes in clinical isolates of Streptococcus pneumoniae from multiple medical centers in Lebanon and assessed the serotype distribution in relation to these mechanism(s) of resistance and the source of isolate recovery.
Methods
Forty four macrolide resistant and 21 macrolide susceptible S. pneumoniae clinical isolates were tested for antimicrobial susceptibility according to CLSI guidelines (2008) and underwent molecular characterization. Serotyping of these isolates was performed by Multiplex PCR-based serotype deduction using CDC protocols. PCR amplification of macrolide resistant erm (encoding methylase) and mef (encoding macrolide efflux pump protein) genes was carried out.
Results
Among 44 isolates resistant to erythromycin, 35 were resistant …
学术搜索中的文章
N Taha, GF Araj, RH Wakim, SS Kanj, ZA Kanafani… - Annals of clinical microbiology and antimicrobials, 2012