作者
Victor Llombart, Albert Antolin-Fontes, Alejandro Bustamante, Dolors Giralt, Natalia S Rost, Karen Furie, Kensaku Shibazaki, Murat Biteker, Jose Castillo, Manuel Rodriguez-Yanez, Ana Catarina Fonseca, Tetsu Watanabe, Francisco Purroy, Wu Zhixin, Thorleif Etgen, Naohisa Hosomi, Scott Reza Jafarian Kerman, Jagdish C Sharma, Carolin Knauer, Estevo Santamarina, George Giannakoulas, Teresa Garcia-Berrocoso, Joan Montaner
发表日期
2015/5
来源
Stroke
卷号
46
期号
5
页码范围
1187-1195
出版商
Lippincott Williams & Wilkins
简介
Background and Purpose
Determining the underlying cause of stroke is important to optimize secondary prevention treatment. Increased blood levels of natriuretic peptides (B-type natriuretic peptide/N-terminal pro-BNP [BNP/NT-proBNP]) have been repeatedly associated with cardioembolic stroke. Here, we evaluate their clinical value as pathogenic biomarkers for stroke through a literature systematic review and individual participants’ data meta-analysis.
Methods
We searched publications in PubMed database until November 2013 that compared BNP and NT-proBNP circulating levels among stroke causes. Standardized individual participants’ data were collected to estimate predictive values of BNP/NT-proBNP for cardioembolic stroke. Dichotomized BNP/NT-proBNP levels were included in logistic regression models together with clinical variables to assess the sensitivity and specificity to identify cardioembolic …
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V Llombart, A Antolin-Fontes, A Bustamante, D Giralt… - Stroke, 2015